ReviewPost screenLipid-polymer hybrid nanoparticle-mediated therapeutics delivery: advances and challenges

- This review gives an update of LPHNPs manufacturing process and therapeutics delivery
- LPHNPs can be used for improving the therapeutic efficacy of drugs, genes and imaging agents.
- Recent advances in LPHNPs preparation in pilot scale hold the key to progress.
- Exploring the novel hybrid NPs such as cell membrane functionalized NPs is an emerging as an interesting and central research topic.

With rapid advances in nanomedicine, lipid-polymer hybrid nanoparticles (LPHNPs) have emerged as promising nanocarriers for several biomedical applications, including therapeutics delivery and biomedical imaging. Significant research has been dedicated to biomimetic or targeting functionalization, as well as controlled and image-guided drug-release capabilities. Despite this research, the clinical translation of LPHNP-mediated therapeutics delivery has progressed incrementally. In this review, we discuss the recent advances in and challenges to the development and application of LPHNPs, present examples to demonstrate the advantages of LPHNPs in therapeutics delivery and imaging applications, and discuss the translational obstacles to LPHNP technology.