کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5521346 | 1545301 | 2018 | 12 صفحه PDF | دانلود رایگان |
We developed and evaluated a solvent-free injection molding (IM) coating technology that could be suitable for continuous manufacturing via incorporation with IM tableting. Coating formulations (coating polymers and plasticizers) were prepared using hot-melt extrusion and screened via stress-strain analysis employing a universal testing machine. Selected coating formulations were studied for their melt flow characteristics. Tablets were coated using a vertical injection molding unit. Process parameters like softening temperature, injection pressure, and cooling temperature played a very important role in IM coating processing. IM coating employing polyethylene oxide (PEO) based formulations required sufficient room humidity (>30% RH) to avoid immediate cracks, whereas other formulations were insensitive to the room humidity. Tested formulations based on Eudrajit E PO and Kollicoat IR had unsuitable mechanical properties. Three coating formulations based on hydroxypropyl pea starch, PEO 1,000,000 and Opadry had favorable mechanical (<700Â MPa Young's modulus, >35% elongation, >95Â ÃÂ 104Â J/m3 toughness) and melt flow (>0.4Â g/min) characteristics, that rendered acceptable IM coats. These three formulations increased the dissolution time by 10, 15 and 35Â min, respectively (75% drug release), compared to the uncoated tablets (15Â min). Coated tablets stored in several environmental conditions remained stable to cracking for the evaluated 8-week time period.
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Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 122, January 2018, Pages 25-36