|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5523119||1546079||2017||4 صفحه PDF||سفارش دهید||دانلود کنید|
- We tested the effect of neostigmine on equine preovulatory follicle contractility.
- We identified the contractility effects of three single doses of neostigmine.
- We showed that neostigmine increases contractility in equine preovulatory follicles.
- We showed that neostigmine at 10â6Â M and 10â4Â M induced a phasic contraction.
- We showed that neostigmine at 10â5Â M induced a tonic contraction.
In this study, the Authors investigated the modulatory effect of three single doses (10â6, 10â5, and 10â4Â M) of neostigmine on the spontaneous contractility of equine pre-ovulatory follicles in an isolated organ bath, to establish the relationship between this acetylcholinesterase inhibitor and ovulation, in the mare. The results indicate that neostigmine increases pre-ovulatory contractility in equine follicles at each dose, but in a different manner. Indeed, the rise in contractility induced by neostigmine at 10â6Â M and 10â4Â M was phasic, while at 10â5Â M it was tonic. The data obtained indicate possible implications of these drugs in the pharmacological modulation of equine ovulation.
Journal: Theriogenology - Volume 90, 1 March 2017, Pages 74-77