کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5524179 | 1546240 | 2017 | 8 صفحه PDF | دانلود رایگان |
- The BCNU, etoposide, cytarabine, and melphalan with ibritumomab tiuxetan (Z-BEAM) conditioning regimen for autologous hematopoietic cell transplantation is potentially effective in diffuse large B cell lymphoma
- Nonrelapse mortality rates are low, with little short- or long-term toxicity
- Augmenting BCNU, etoposide, cytarabine, and melphalan conditioning with radioimmunotherapy is feasible.
Standard-dose 90yttrium-ibritumomab tiuxetan (.4 mci/kg) together with high-dose BEAM (BCNU, etoposide, cytarabine, and melphalan) (Z-BEAM) has been shown to be a well-tolerated autologous hematopoietic stem cell transplantation preparative regimen for non-Hodgkin lymphoma. We report the outcomes of a single-center, single-arm phase II trial of Z-BEAM conditioning in high-risk CD20+ non-Hodgkin lymphoma histologic strata: diffuse large B cell (DLBCL), mantle cell, follicular, and transformed. Robust overall survival and notably low nonrelapse mortality rates (.9% at day +100 for the entire cohort), with few short- and long-term toxicities, confirm the safety and tolerability of the regimen. In addition, despite a high proportion of induction failure patients (46%), the promising response and progression-free survival (PFS) rates seen in DLBCL (3-year PFS: 71%; 95% confidence interval, 55 to 82%), support the premise that the Z-BEAM regimen is particularly effective in this histologic subtype. The role of Z-BEAM in other strata is less clear in the context of the emergence of novel agents.
Journal: Biology of Blood and Marrow Transplantation - Volume 23, Issue 6, June 2017, Pages 922-929