|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5524258||1401412||2017||3 صفحه PDF||ندارد||دانلود کنید|
â¢The safety and efficacy of peripheral blood stem cell collecting procedures in POEMS syndrome were investigatedâ¢The proportions of good mobilizers were comparable between cyclophosphamideâplus granulocyte colonyâstimulating factorâor granulocyte colonyâstimulating factor alone mobilizationâ¢Mobilization-related complications were significantly higher in the cyclophosphamideâplus granulocyte colonyâstimulating factorâ groupâ¢Patients in granulocyte colonyâstimulating factor alone group achieved a significant decrease in the serum vascular endothelial growth factor levels by induction therapy before peripheral blood stem cell collectionâ¢Appropriate induction therapy followed by granulocyte colonyâstimulating factor monotherapy is an optimal strategy for peripheral blood stem cell collection in POEMS syndrome
Although autologous stem cell transplantation can achieve excellent responses in patients with POEMS syndrome, the optimal regimen for peripheral blood stem cell (PBSC) collection is still controversial. We retrospectively investigated the safety and efficacy of 41 PBSC collecting procedures in 37 patients with POEMS syndrome. PBSC mobilization was performed using cyclophosphamideâ+ granulocyte colonyâstimulating factor (G-CSF) (CG, nâ=â14) or G-CSF alone (G, nâ=â27). Twelve (85.7%) patients in the CG group and all (100%) patients in the G group received induction chemotherapy before PBSC collection. The proportions of good mobilizers (â¥2.0âÃâ106 CD34+ cells/kg) were comparable between the 2 groups (CG versus G: 78.6% versus 70.4%, Pâ=â.71). Two (14.3%) patients in the CG group developed severe capillary leak symptoms during the PBSC mobilization period, whereas no patient in the G group experienced severe adverse events. Appropriate induction therapies followed by the G-CSF monotherapy compose an optimal strategy for PBSC collection.
Journal: Biology of Blood and Marrow Transplantation - Volume 23, Issue 2, February 2017, Pages 361-363