کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5524258 1401412 2017 3 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
Safety and Efficacy of Granulocyte Colony-Stimulating Factor Monotherapy for Peripheral Blood Stem Cell Collection in POEMS Syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Safety and Efficacy of Granulocyte Colony-Stimulating Factor Monotherapy for Peripheral Blood Stem Cell Collection in POEMS Syndrome
چکیده انگلیسی


- The safety and efficacy of peripheral blood stem cell collecting procedures in POEMS syndrome were investigated
- The proportions of good mobilizers were comparable between cyclophosphamide plus granulocyte colony-stimulating factor or granulocyte colony-stimulating factor alone mobilization
- Mobilization-related complications were significantly higher in the cyclophosphamide plus granulocyte colony-stimulating factor  group
- Patients in granulocyte colony-stimulating factor alone group achieved a significant decrease in the serum vascular endothelial growth factor levels by induction therapy before peripheral blood stem cell collection
- Appropriate induction therapy followed by granulocyte colony-stimulating factor monotherapy is an optimal strategy for peripheral blood stem cell collection in POEMS syndrome

Although autologous stem cell transplantation can achieve excellent responses in patients with POEMS syndrome, the optimal regimen for peripheral blood stem cell (PBSC) collection is still controversial. We retrospectively investigated the safety and efficacy of 41 PBSC collecting procedures in 37 patients with POEMS syndrome. PBSC mobilization was performed using cyclophosphamide + granulocyte colony-stimulating factor (G-CSF) (CG, n = 14) or G-CSF alone (G, n = 27). Twelve (85.7%) patients in the CG group and all (100%) patients in the G group received induction chemotherapy before PBSC collection. The proportions of good mobilizers (≥2.0 × 106 CD34+ cells/kg) were comparable between the 2 groups (CG versus G: 78.6% versus 70.4%, P = .71). Two (14.3%) patients in the CG group developed severe capillary leak symptoms during the PBSC mobilization period, whereas no patient in the G group experienced severe adverse events. Appropriate induction therapies followed by the G-CSF monotherapy compose an optimal strategy for PBSC collection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biology of Blood and Marrow Transplantation - Volume 23, Issue 2, February 2017, Pages 361-363
نویسندگان
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