کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5528822 1548552 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GSTP1 and XRCC1 polymorphisms and DNA damage in agricultural workers exposed to pesticides
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
GSTP1 and XRCC1 polymorphisms and DNA damage in agricultural workers exposed to pesticides
چکیده انگلیسی


- Prevalence of genotypes of metabolic GSTP1 was studied.
- Prevalence of genotypes of DNA-repair XRCC1 was studied.
- DNA damage was estimated by comet assay.
- Correlations of genotypes with DNA damage were estimated in pesticide sprayers.
- Results can be applied to monitor risks among agricultural workers.

Pesticide exposure may be associated with increased risk of genotoxicity and carcinogenesis. These risks may be affected by polymorphisms of genes for glutathione transferase-dependent metabolism of pesticides and for DNA repair. We studied the prevalence of GSTP1 and XRCC1 polymorphisms and their possible correlation with DNA damage following prolonged pesticide exposure. DNA damage was estimated by the comet assay in peripheral blood samples from 51 pesticide-exposed workers and 50 controls. GSTP1 (105) and XRCC1 (399 and 194) genotypes were identified by restriction fragment length analysis. Individuals carrying theGSTP1 Ile-Ile or XRCC1399 Arg-Arg genotypes showed greater DNA damage than observed for other alleles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 819, July 2017, Pages 20-25
نویسندگان
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