کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5529514 | 1401700 | 2017 | 7 صفحه PDF | دانلود رایگان |
Background and purposeInvolved site radiotherapy clinical target volume (CTV) for lymphoma requires an expansion to account for the absence of radiotherapy treatment-position pre-chemotherapy imaging, which is not widely implemented. This prospective imaging study aims to quantify CTV expansion required for neck radiotherapy.Materials and methods10 patients from a prospective single centre imaging study underwent a pre-chemotherapy FDG-PET-CT in both the diagnostic and radiotherapy treatment position, and subsequently received neck radiotherapy post-chemotherapy. CTVINRT and CTVdiagPET were delineated on the planning CT, following co-registration of the radiotherapy position PET-CT and side-by-side assessment of diagnostic PET-CT respectively.ResultsIntra-observer variability was limited, with delineation of CTVINRT highly reproducible and slightly lower for CTVdiagPET (mean DICE 0.88 and 0.8 respectively). Superiorly, CTVdiagPET varied by â10 to +15Â mm from CTVINRT. Inferiorly, CTVdiagPET varied by â18 to +6Â mm from CTVINRT. Comparing CTVINRT and CTVdiagPET in the axial plane, the mean DICE was 0.74. Mean sensitivity index was 0.75 (range 0.59-0.91), showing that on average 75% of the CTVINRT was encompassed by the CTVdiagPET.ConclusionsIn the absence of treatment-position PET-CT, CTV expansion cranially and caudally by 10Â mm and 18Â mm respectively, along with generous contouring in the axial plane, was required to encompass pre-chemotherapy disease.
Journal: Radiotherapy and Oncology - Volume 124, Issue 1, July 2017, Pages 161-167