|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5529739||1401705||2017||6 صفحه PDF||سفارش دهید||دانلود کنید|
PurposeTo evaluate long-term radiation toxicity and biochemical control of two moderately hypofractionated radiotherapy regimens for prostate cancer.Material and methodsEligible men with localized prostate cancer received image-guided intensity modulated radiotherapy (IG-IMRT) to a dose of 60 or 66Â Gy in 3Â Gy fractions in a phase II trial. Endpoints included late gastrointestinal (GI) and genitourinary (GU) toxicity and biochemical failure (FFBF).ResultsNinety-six men received 60Â Gy and 27 received 66Â Gy. Accrual to the 66Â Gy cohort terminated early due to excessive Grade 3-4 late toxicity. Median follow-up was 128Â months (60Â Gy) and 108Â months (66Â Gy). In the 60Â Gy cohort, cumulative late Grade â©¾2 GI and GU toxicity at 8Â years was 4% and 12% respectively. In the 66Â Gy cohort, late Grade â©¾2 GI and GU toxicity was 21% and 4% respectively at 8Â years. The 5- and 8-year FFBF for 60Â Gy was 81% and 66%, and for 66Â Gy was 88% and 80%.ConclusionsModerate hypofractionation with IG-IMRT to 60Â Gy was associated with favorable late toxicity although late urinary toxicity and biochemical failures were observed beyond 5Â years. Dose escalation to 66Â Gy was associated with significantly worse late toxicity.
Journal: Radiotherapy and Oncology - Volume 122, Issue 1, January 2017, Pages 93-98