کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5530003 1401711 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inflammatory bowel diseaseAcute toxicity and surgical complications after preoperative (chemo)radiation therapy for rectal cancer in patients with inflammatory bowel disease
ترجمه فارسی عنوان
بیماری التهابی روده سمیت مسمومیت و عوارض جراحی پس از پرتودرمانی قبل از عمل (شیمیایی) برای سرطان رکتوم در بیماران مبتلا به بیماری التهابی روده
کلمات کلیدی
بیماری روده التهابی سرطان رکتوم درمان قبل از عمل، درمان شیمی درمانی، پرتودرمانی کوتاه مدت،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

PurposePreoperative therapy reduces local recurrences and may facilitate surgery in rectal cancer patients. However, in patients with inflammatory bowel disease (IBD) this treatment is often withheld due to the perceived risk of excessive side-effects, even though evidence is limited. The purpose of this study is to investigate the effects of preoperative therapy on acute toxicity and post-operative complications in IBD patients with rectal cancer.MethodsThe Dutch pathology registry (PALGA) was searched for patients with IBD and rectal cancer treated between January 1991 and May 2010. Histopathology and clinical charts were reviewed to confirm IBD diagnosis and evaluate clinical and pathological characteristics.ResultsOut of 161 patients, 66 received preoperative therapy (41%), including short-course radiation therapy (SC-RT), long course radiation therapy (LC-RT), and chemoradiation therapy (CRT) in 32, 13, and 21 patients respectively. Grade ≥ 3 acute toxicity occurred in 0 patients (0.0%), 1 patient (7.7%), and 6 patients (28.6%) respectively (p = 0.004). Systemic corticosteroids were used by 10.5% of patients at time of treatment. Grade ≥ 3 post-operative 30-day complication rate (28.1% overall) was not associated with type of preoperative therapy.ConclusionResults did not show excessive rates of toxicity or post-operative complications and support the use of standard preoperative therapies for rectal cancer (especially SC-RT) in IBD patients with relatively indolent disease. Caution is warranted in patients with active IBD, since the exact impact of active bowel inflammation could not be determined retrospectively. Prospective studies should investigate the influence of active IBD on acute and late toxicity in patients receiving pelvic irradiation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 123, Issue 1, April 2017, Pages 147-153
نویسندگان
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