کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5530560 | 1549313 | 2017 | 4 صفحه PDF | دانلود رایگان |
- NFAT-AP1 complexes drive a transcriptional program of T cell activation.
- Other NFAT complexes favor upregulation of genes that oppose activation.
- Specific NFAT complexes could be therapeutic targets in immune disease.
A cornerstone of the adaptive immune response is the T cell receptor (TcR)-calcium-calcineurin signalling pathway leading to T cell activation. The 'nuclear factor of activated T cells' proteins NFAT1, NFAT2, and NFAT4 are transcription factors that promote expression of a panel of genes required for activation. It has become apparent that these same NFAT transcription factors underlie an alternative transcriptional program in T cells that serves to limit the immune response. This duality in NFAT transcriptional functions raises the possibility that NFAT transcriptional complexes could be targeted therapeutically to alter the relative strength of the effector and alternative transcriptional programs, thereby modulating immune responses.
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Journal: Cell Calcium - Volume 63, May 2017, Pages 66-69