CommentaryRyanodine receptor resolution revolution: Implications for InsP3 receptors?

- High resolution cryo-EM ryanodine receptor (RyR1) structures have been determined.
- The structures reveal binding sites for Ca2+, ATP, caffeine and ryanodine.
- The structures have been compared with an InsP3 receptor structure.
- RyR structures provide insights into Ca2+ and ATP binding sites in InsP3 receptors.

220