PPAR-γ and CYP46A1 genes polymorphism is associated with Primary Open Angle Glaucoma (POAG) in hypertensive North Indians

BackgroundInvolvement of genetic factors like gene polymorphisms was found to contribute significantly to development and progression of Primary Open Angle Glaucoma (POAG) in the last few decades.Aim of studyThe present study was carried out to investigate association of PPAR-γ (rs10865710) and CYP46A1 (rs754203) gene polymorphism with development of POAG in hypertensive North Indians.Patients and methodsStudy included 328 individuals, 226 as POAG cases and 102 controls. PPAR-γ and CYP46A1 gene polymorphism was evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The genotypic and allelic frequency distribution in patients and controls was analyzed by SPSS (version 12.0).ResultsIn CYP46A1 gene polymorphism, TT genotype and T allele were found to be associated with a significantly decreased risk of POAG whereas the CT, CC genotypes and C allele were associated with an increased risk of POAG in both hypertensive and normotensive individuals. In PPAR-γ gene polymorphism, only GG genotype was nearly associated with POAG in only hypertensive cases.ConclusionsCYP46A1 (rs754203) gene polymorphism was associated with POAG in both hypertensive and normotensive patients whereas, only GG genotype of PPAR-γ (rs10865710) SNP shows significant association with POAG in hypertensive POAG patients.