کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5532535 1549986 2017 3 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Video articleReal-time visualization of immune cell clearance of Aspergillus fumigatus spores and hyphae
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موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
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Video articleReal-time visualization of immune cell clearance of Aspergillus fumigatus spores and hyphae
چکیده انگلیسی


- Innate phagocytes provide effective host defense against Aspergillus fumigatus.
- Transparency of zebrafish larvae offers objective visualization of host/microbe interactions.
- Live intravital imaging offers insight into host cell recruitment, fungal response, and interaction outcome.

Invasive aspergillosis (IA) is a disease of the immunocompromised host and generally caused by the opportunistic fungal pathogen Aspergillus fumigatus. While both host and fungal factors contribute to disease severity and outcome, there are fundamental features of IA development including fungal morphological transition from infectious conidia to tissue-penetrating hyphae as well as host defenses rooted in mechanisms of innate phagocyte function. Here we address recent advances in the field and use real-time in vivo imaging in the larval zebrafish to visually highlight conserved vertebrate innate immune behaviors including macrophage phagocytosis of conidia and neutrophil responses post-germination.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fungal Genetics and Biology - Volume 105, August 2017, Pages 52-54
نویسندگان
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