|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5532535||1549986||2017||3 صفحه PDF||سفارش دهید||دانلود کنید|
- Innate phagocytes provide effective host defense against Aspergillus fumigatus.
- Transparency of zebrafish larvae offers objective visualization of host/microbe interactions.
- Live intravital imaging offers insight into host cell recruitment, fungal response, and interaction outcome.
Invasive aspergillosis (IA) is a disease of the immunocompromised host and generally caused by the opportunistic fungal pathogen Aspergillus fumigatus. While both host and fungal factors contribute to disease severity and outcome, there are fundamental features of IA development including fungal morphological transition from infectious conidia to tissue-penetrating hyphae as well as host defenses rooted in mechanisms of innate phagocyte function. Here we address recent advances in the field and use real-time in vivo imaging in the larval zebrafish to visually highlight conserved vertebrate innate immune behaviors including macrophage phagocytosis of conidia and neutrophil responses post-germination.
Journal: Fungal Genetics and Biology - Volume 105, August 2017, Pages 52-54