ReviewNon-Coding RNA Molecules Connect Calorie Restriction and Lifespan

- CR extends lifespan by modulating fundamental biological processes including genome stability and metabolism.
- CR modulates the expression of several classes of ncRNAs including microRNAs and long ncRNAs.
- CR-responsive ncRNAs are emerging as regulators of processes and diseases linked to aging.

Calorie restriction (CR) is a broadly effective environmental intervention that extends life by operating through numerous biological processes. Here, we discuss how non-coding RNA (ncRNA) molecules act as mediators and targets of lifespan-extending CR. We also highlight how these RNA molecules connect CR to its effects on genome stability, cell metabolism, programmed cell death, senescence, cancer, and neurodegeneration. We anticipate that an advanced understanding of the connections between CR and non-coding RNA will provide unique insights into aging mechanisms while pointing to novel approaches aimed at modulating aging and age-related diseases.

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