کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5533142 | 1402103 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
BreviaThe Role of Hexon Protein as a Molecular Mold in Patterning the Protein IX Organization in Human Adenoviruses
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Adenoviruses are respiratory, ocular and enteric pathogens that form complex capsids, which are assembled from seven different structural proteins and composed of several core proteins that closely interact with the packaged dsDNA genome. The recent near-atomic resolution structures revealed that the interlacing continuous hexagonal network formed by the protein IX molecules is conserved among different human adenoviruses (HAdVs), but not in non-HAdVs. In this report, we propose a distinct role for the hexon protein as a “molecular mold” in enabling the formation of such hexagonal protein IX network that has been shown to preserve the stability and infectivity of HAdVs.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Biology - Volume 429, Issue 18, 1 September 2017, Pages 2747-2751
Journal: Journal of Molecular Biology - Volume 429, Issue 18, 1 September 2017, Pages 2747-2751
نویسندگان
Vijay S. Reddy,