کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5534230 1550838 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewFunction of CYP11A1 in the mitochondria
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
ReviewFunction of CYP11A1 in the mitochondria
چکیده انگلیسی


- CYP11A1 catalyzes the first step of steroidogenesis in mitochondria using electrons transported from the membrane.
- CYP11A1 affects the structure of mitochondrial membranes.
- Mitochondrial membranes are important for functions of CYP11A1 and steroidogenesis.

Steroids are synthesized from the adrenal glands and gonads by enzymes of the cytochromes P450 and hydroxysteroid dehydrogenase in nature. These enzymes are located in the membrane of endoplasmic reticulum and mitochondria to catalyze redox reactions using electrons transported from the membrane. In the mitochondria, steroidogenic enzymes are inserted into the inner membrane with the bulk of the protein facing the matrix. They are not only important for steroid biosynthesis, their presence also affects mitochondrial morphology. Mitochondria undergo constant fission and fusion; they play important roles in energy production, apoptosis, and metabolism. Their defects often lead to human diseases. Mitochondrial cristae are usually lamellar in shape, but can also assume different shapes. Cristae in the mitochondria of steroidogenic cells are tubular-vesicular in shape. This cristae shape is also related to the degree of steroidogenic cell differentiation. Steroidogenic enzymes in the mitochondria appear to have a dual role in shaping the morphology of mitochondria and in steroid production.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 441, 5 February 2017, Pages 55-61
نویسندگان
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