کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5545457 1555325 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Experimental infection of mandarin duck with highly pathogenic avian influenza A (H5N8 and H5N1) viruses
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Experimental infection of mandarin duck with highly pathogenic avian influenza A (H5N8 and H5N1) viruses
چکیده انگلیسی


- Presently, we determined the pathogenicity and transmissibility of the three different clades H5 viruses in mandarin ducks to compare the potential of wild bird infection.
- None of mandarin ducks with H5N8 and H5N1 viruses caused severe clinical signs and mortality and the gross lesions were only observed in a few tissues of mandarin ducks; viral replication and shedding were greater in H5N8-infected ducks than in H5N1-infected ducks.

A highly pathogenic avian influenza (HPAI) H5N8 virus was first detected in poultry and wild birds in South Korea in January 2014. Here, we determined the pathogenicity and transmissibility of three different clades of H5 viruses in mandarin ducks to examine the potential for wild bird infection. H5N8 (clade 2.3.4.4) replicated more efficiently in the upper and lower respiratory tract of mandarin ducks than two previously identified H5N1 virus clades (clades 2.2 and 2.3.2.1). However, none of the mandarin ducks infected with H5N8 and H5N1 viruses showed severe clinical signs or mortality, and gross lesions were only observed in a few tissues. Viral replication and shedding were greater in H5N8-infected ducks than in H5N1-infected ducks. Recovery of all viruses from control duck in contact with infected ducks indicated that the highly pathogenic H5 viruses spread horizontally through contact. Taken together, these results suggest that H5N8 viruses spread efficiently in mandarin ducks. Further studies of pathogenicity in wild birds are required to examine possible long-distance dissemination via migration routes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Microbiology - Volume 198, January 2017, Pages 59-63
نویسندگان
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