|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5545527||1402702||2017||3 صفحه PDF||ندارد||دانلود کنید|
â¢The treatment with spinosad/milbemycin oxime had a higher reduction in Toxocara spp. positive dogs.â¢Spinosad and milbemycin oxime are safe and have effective control for the treatment of Toxocara spp. infection.â¢This study showed treatment of female pups with ivermectin/praziquantel was significantly less effective than treatment with milbemycin/spinosad at 14Â days post-treatment.
Toxocara canis is one of the most important zoonotic parasites of dogs. The aim of the present study was to compare the efficacy of spinosad/milbemycin oxime and ivermectin/praziquantel in dogs naturally infected with Toxocara spp. We studied 200 dogs with a positive diagnosis of Toxocara spp. Through coproparasitoscopic analysis, two study groups of 100 dogs each were assigned: spinosad/milbemycin oxime at a dose of 30â60Â mg/kg and 0.75â1.0Â mg/kg, respectively, or ivermectin/praziquantel administered at a dose of 0.2Â mg/kg and 5Â mg/kg, respectively. Both groups received a single dose. Three stool samples, one at day 0 before treatment, and at 14 and 28Â days post-treatment were examined using concentration-flotation techniques. In both treatments, the number of Toxocara spp. eggs decreased; with spinosad/milbemycin oxime treatment, eggs decreased by 87% at 14Â days (PÂ =Â 0.008) and 94% at 28Â days after treatment, compared with 71% at day 14 and 88% at day 28 in dogs medicated with ivermectin/praziquantel. The spinosad/milbemycin oxime treated group showed a greater decrease in the number of Toxocara spp. positive dogs compared to the group receiving ivermectin/praziquantel.
Journal: Veterinary Parasitology - Volume 247, 30 November 2017, Pages 77-79