کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5548004 1556461 2018 7 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
A pH-responsive composite hydrogel beads based on agar and alginate for oral drug delivery
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
A pH-responsive composite hydrogel beads based on agar and alginate for oral drug delivery
چکیده انگلیسی

To improve the mechanical strength of calcium alginate hydrogel and obtain sustained drug delivery, the pH-sensitive composite gel beads composed of agar and alginate were prepared in the presence of agar as a modifying agent. All the obtained gel beads were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The influence of the content of agar on the properties of the hydrogel including mechanical strength, swelling and drug release behavior was evaluated in simulated intestinal fluid (pH 7.4) and gastric fluid (pH 2.1) at 37 °C. Results illustrated that mechanical strength of agar/alginate beads (AALB) was significantly improved compared with the native alginate beads (NALB) without agar. The swelling and drug release behavior of AALB was markedly dependent on the content of agar. The gel beads with higher content of agar exhibited a lower rate of swelling and drug release within 720 min. Drug release behavior of AALB was further studied in simulated intestinal fluid and gastric fluid, and results showed that AALB could serve as a potential candidate for controlled drug delivery.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 43, February 2018, Pages 12-18
نویسندگان
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