کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5548014 1402816 2018 6 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
Development of liposomal formulations to potentiate natural lovastatin inhibitory activity towards 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Development of liposomal formulations to potentiate natural lovastatin inhibitory activity towards 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase
چکیده انگلیسی

Liposomal formulations were obtained mixing 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) with synthetic lovastatin or lovastatin extracted from Red Yeast Rice (RYR) to prepare a vehicle able to overcome both the disadvantage of lovastatin, i.e its poor oral bioavailability and side effects. Liposomal formulation obtained combining DOPC, DOPE and hydro-alcoholic extract of RYR showed optimal physico-chemical, mechanical and thermal characteristics and the strongest inhibition activity versus 3-hydroxy-3-Methyl glutaryl coenzyme A (HMG-CoA) reductase.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 43, February 2018, Pages 107-112
نویسندگان
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