کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5548095 1556464 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Valsartan floating bioadhesive compression-coated mini-tablets: Formulation and pharmacokinetics
ترجمه فارسی عنوان
مایع قرصهای فلورسنت شناور مضر فلورسانس: فرمولاسیون و فارماکوکینتیک
کلمات کلیدی
تحویل داروهای بی هوشی، قابلیت دسترسی بیولوژیک، زمان اقامت معده، احتباس گوارشی، تحویل دارو شناور، قرص مینی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

An attempt is made in the present study to develop the valsartan floating bioadhesive compression-coated mini-tablets. Among the various methods described, combination of floating and bioadhesive drug delivery systems is a promising way in gastro retention with few limitations, which has a great impact on the drug delivery to its intended site of administration. Mini-tablets have the advantages of both tablets as well as multiparticulates like pellets. The prepared mini-tablets were evaluated for weight variation, thickness, friability, hardness, drug content, in vitro buoyancy, in vitro release and in vivo studies. Prepared core mini-tablets were compression coated using polymers such as HPMC K4M and Carbopol 934P. From the results, formulations with HPMC K4M with Carbopol 934P in 1:1 ratio showed controlled release. Formulation F3 showed a satisfactory dissolution profile, detachment stress and floating characteristics, which can increase the gastric residence time as well as bioavailability. Pharmacokinetic studies of F3 formulation in albino male rabbits showed 2.25-fold higher bioavailability and 1.5-fold higher Cmax compared to immediate release core mini-tablets. Hence development of valsartan floating mini-tablets using combination of floating drug delivery and bioadhesive drug delivery systems is the best way to obtain gastro retention to gain therapeutic benefits.

112

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 40, August 2017, Pages 66-72
نویسندگان
, , ,