کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5548097 1556464 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of retrograded starch as excipient for controlled release matrix tablets
ترجمه فارسی عنوان
ارزیابی نشاسته پساب مجدد به عنوان افزودنی برای قرصهای ماتریس کنترل آزاد
کلمات کلیدی
نشاسته زردآلو، پکتین، پلیمرهای زیست تخریب پذیر، قرص ماتریکس، انحلال،
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

High amylose starch (HAS) was retrograded by two different methods. The physicochemical properties of the retrograded materials were evaluated and structural changes were highlighted. Micromeritics properties were demonstrated as suitable for the compression process. Hydrophilic matrices were prepared by dry granulation of the retrograded starch. The in vitro release of diclofenac sodium (DS) in media with different pH values (1.2 and 7.4) was evaluated. The release profiles demonstrated the lowering of drug release rates in acid medium, mainly when pectin was associated to the matrix by physical mixture. In enteric medium, increased rates of drug release were observed, so that t80% occurred at approximately 60 min, while for the tablets obtained with HAS, this time was of approximately 120 min. The matrix obtained with pectin (during retrogradation and by physical mixture) enabled a more effective control over the drug release rates, so that t80% of DS was 150 min and 210 min, respectively.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 40, August 2017, Pages 83-94
نویسندگان
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