کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5548206 1556467 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fabrication of functionalized porous silica nanoparticles and their controlled release behavior
ترجمه فارسی عنوان
تولید نانوذرات سیلیس متخلخل عملکردی و رفتار آزادی کنترل شده آنها
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

Thiol and amine difunctionalized porous silica (pSiO2-SH/NH2) nanoparticles (NPs) were prepared by condensation. The obtained pSiO2-SH/NH2 NPs present uniform spheres with size of 55 nm. Folic acid (FA) as a tumor targeting agent was conjugated on the surface of pSiO2 NPs by amide linkage (pSiO2-SH/FA NPs), and captopril (Cap) as test drug was used to evaluate the releasing behavior. Results indicated that Cap is easily encapsulated into the pores of pSiO2-SH/FA NPs, which can further react with the inner thiols to form disulfide bonds. The Cap release from pSiO2-Cap/FA nanocarriers can be controlled by dithiothreitol (DTT) or reduced glutathione (GSH). The pSiO2-SH/FA nanocarriers showed low cytotoxicity and redox-responsive drug release.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 37, February 2017, Pages 38-45
نویسندگان
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