کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5548208 1556467 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brain delivery of baclofen as a hydrophilic drug by nanolipid carriers: Characteristics and pharmacokinetics evaluation
ترجمه فارسی عنوان
تحویل مغز باکلوفن به عنوان یک داروی هیدروفیلی با استفاده از نانولایپید: مشخصات و ارزیابی فارماکوکینتیک
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

Formulation of baclofen in lipid-based nanoparticles may be helpful to overcome its difficulties in order to reach the site of action in the CNS. This study reports production, characterization and pharmacokinetics evaluation of baclofen loaded lipid nano-carriers. Lipid nano-carriers containing baclofen were prepared by using double emulsion solvent evaporation method and physicochemical characteristics of prepared nanoparticles were evaluated. The selected formulation was administered on rat model to be compared with an aqueous drug solution. Plasma and brain concentrations of drug and pharmacokinetics parameters were compared. Nanostructured lipid carriers (NLC) formulation showed better physicochemical properties than solid lipid nanoparticles (SLNs). Also, the formulation of baclofen by NLC increased the half-life of drug in plasma and brain up to 10 and 1.5 times respectively compared to the solution formulation. Results revealed a more significant and prolonged effect of baclofen-NLC in comparison with baclofen solution in both plasma and brain mediums that emphasize and prove theories on the formulation of hydrophilic drug in NLCs can be a solution for target drug delivery to the brain.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 37, February 2017, Pages 67-73
نویسندگان
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