کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5548620 1556546 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MEN1 and microRNAs: The link between sporadic pituitary, parathyroid and adrenocortical tumors?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
MEN1 and microRNAs: The link between sporadic pituitary, parathyroid and adrenocortical tumors?
چکیده انگلیسی

Sporadic tumors of the pituitary, parathyroids and adrenal cortex are unique, as their benign forms are very common, but malignant forms are exceptionally rare. Hereditary forms of these tumors occur in multiple endocrine neoplasia syndrome type 1 (MEN1). We hypothesize that the pathogenic link among the sporadic tumors of these organs of different germ layers might be represented by common molecular pathways involving the MEN1 gene and microRNAs (miR). miR-24 might be a microRNA linking the three tumor entities, but other candidates such as miR-142-3p and microRNAs forming the DLK1-MEG3 miRNA cluster might also be of importance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 99, February 2017, Pages 40-44
نویسندگان
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