کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5549004 1556602 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Invited reviewMetabotropic glutamate receptors in cancer
ترجمه فارسی عنوان
بررسی های مورد بررسی گیرنده های گلوتامات ماتوبوتروپیک در سرطان
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Tumor cells consume excessive glutamine for energy and macromolecule synthesis.
- mGluRs play a role in progression and maintenance of brain and non-neuronal tumors.
- Riluzole, a glutamate release inhibitor, can be a radiosensitizer in some cancers.
- mGluR1 participates in crosstalk with the PI3K/AKT/mTOR and the IGF-1R pathways.
- Functional mGluR1 may enhance angiogenesis in melanoma and breast cancer.

Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers. More recently, aberrant glutamate signaling has been shown to participate in the transformation and maintenance of various cancer types, including glioma, melanoma skin cancer, breast cancer, and prostate cancer, indicating that genes encoding mGluRs, GRMs, can function as oncogenes. Here, we provide a review on the interactions of mGluRs and their ligand, glutamate, in processes that promote the growth of tumors of neuronal and non-neuronal origins. Further, we discuss the evolution of riluzole, a glutamate release inhibitor approved for amyotrophic lateral sclerosis (ALS), but now fashioned as an mGluR1 inhibitor for melanoma therapy and as a radio-sensitizer for tumors that have metastasized to the brain. With the success of riluzole, it is not far-fetched to believe that other drugs that may act directly or indirectly on other mGluRs can be beneficial for multiple applications.This article is part of the Special Issue entitled 'Metabotropic Glutamate Receptors, 5 years on'.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 115, 15 March 2017, Pages 193-202
نویسندگان
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