کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5550995 1557716 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulatory efficacy of fermented plant extract on the intestinal microflora and lipid profile in mildly hypercholesterolemic individuals
ترجمه فارسی عنوان
اثربخشی تنظیمی عصاره گیاه غنی شده بر روی میکروفلور روده و پروفایل لیپید در افراد مبتلا به هیپرکلسترولمیک خفیف
کلمات کلیدی
پارامترهای تن سنجی، ظرفیت آنتی اکسیدان، عصاره گیاه غنی شده میکرو فلور روده، پروفایل چربی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- Effect of fermented plant extract (FPE) on major intestinal microflora, lipid profile, and antioxidant status were evaluated.
- Body weight, body fat, body mass index were markedly lowered by FPE-administered volunteers.
- Intestinal microflora were considerably modulated by improving beneficial bacteria such as Bifidobacterium spp. and Lactobacillus spp.
- Moreover, lipid profile were significantly reduced on treatment with FPE and thus supported the hypocholesterolemic efficiency of FPE.
- FPE beverage might be beneficial for treating various metabolic disorders such as hypercholesterolemia and hyperlipidemia.

In recent years, the use of fermented plant products to protect against various metabolic syndromes has been increasing enormously. The objective of this study was to check the regulatory efficacy of fermented plant extract (FPE) on intestinal microflora, lipid profile, and antioxidant status in mildly hypercholesterolemic volunteers. Forty-four mildly hypercholesterolemic individuals (cholesterol 180-220 mg/dL) were recruited and assigned to two groups: experimental or placebo. Volunteers were requested to drink either 60 mL of FPE or placebo for 8 weeks. Anthropometric measurements were done in the initial, 4th, 8th, and 10th weeks. The anthropometric parameters such as body weight, body fat, and body mass index were markedly lowered (p < 0.05) on FPE intervention participants. Moreover, the total antioxidant capacity and total phenolics in plasma were considerably increased along with a reduction (p < 0.05) in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) after FPE supplementation. Participants who drank FPE showed a pronounced increase (p < 0.05) in the number of beneficial bacteria such as Bifidobacterium spp. and Lactobacillus spp., whereas the number of harmful bacteria such as Escherichia coli and Clostridium perfringens (p < 0.05) were concomitantly reduced. Furthermore, the lag time of LDL oxidation was substantially ameliorated in FPE-administered group, thus indicating its antioxidative and cardioprotective properties. Treatment with FPE substantially improved the intestinal microflora and thereby positively regulated various physiological functions by lowering the anthropometric parameters, TC, and LDL-c, and remarkably elevated the antioxidant capacity and lag time of LDL oxidation. Therefore, we recommended FPE beverage for combating hypercholesterolemia.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Food and Drug Analysis - Volume 25, Issue 4, October 2017, Pages 819-827
نویسندگان
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