کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5555150 1559628 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytotoxic monoterpenoid indole alkaloids from Alstonia yunnanensis Diels
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Cytotoxic monoterpenoid indole alkaloids from Alstonia yunnanensis Diels
چکیده انگلیسی

The ethanol extract of the aerial parts of Alstonia yunnanensis Diels afforded five new monoterpenoid indole alkaloids, alstiyunnanenines A-E (1-5), along with one known compound, alstoniascholarine I (6). The structures of the isolated compounds were established based on 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic potential using eight tumor cell lines. As a result, alkaloids 4-6 exhibited cytotoxicities against all tested tumor cell lines, especially against osteosarcoma cell lines (SOSP-9607, MG-63, Saos-2, M663) with IC50 values < 6 μM.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 117, March 2017, Pages 79-83
نویسندگان
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