کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5555350 1559749 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of a liver-X-receptor ligand on bleomycin induced pulmonary fibrosis in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The effect of a liver-X-receptor ligand on bleomycin induced pulmonary fibrosis in mice
چکیده انگلیسی


- We made animal model of pulmonary fibrosis with bleomycin.
- We found LXRs agonist T0901317 can attenuate bleomycin induced pulmonary fibrosis.
- After bleomycin treatment, T0901317 can inhibit expression of cytokines and TGF-β1.
- T0901317 can also inhibit NF-κB activity and I κBα degradation.

The liver-X-receptors have shown anti-fibrosis ability in several animal models. Our purpose was to investigate the effect of LXRs in bleomycin induced lung fibrosis in mice. Bleomycin was intratracheally delivered to mice. Some mice were administered a LXR agonist, T0901317. Then mice were evaluated for the development of lung inflammation and fibrosis. T0901317 was able to attenuate the inflammation and fibrosis induced by bleomycin. T0901317 treatment evidently abolished the high level of TGF-β1 and inhibited NF-κB DNA-binding activity in lung. So LXRs may attenuate the progressing of lung fibrosis, providing a potential treatment of IPF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 41, December 2016, Pages 116-121
نویسندگان
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