کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5557855 | 1403185 | 2017 | 7 صفحه PDF | دانلود رایگان |
Alpha-lipoic acid (ALA) is an endogenous molecule with pleiotropic effects, including antioxidant and antiinflammatory activity mediated by NF-kB nuclear factor, that has the potential to regulate pro- and anti-inflammatory cytokines. ALA-induced downregulation of two major pro-inflammatory cytokines, IL-1B and IL-6, has been ascertained in different tissues and experimental models.In pregnant women, ALA-dependent modulation of inflammation is beneficial for the implantation and the management of threatened miscarriage and preterm delivery.Recent data indicate that IL-1B and IL-6 expression are modulated by DNA methylation; we previously demonstrated that hypomethylation of these two genes is associated to increased expression in human brain.We then investigated whether ALA-dependent IL-1B and IL-6 downregulation is mediated by epigenetic changes in ovarian experimental models, studying the DNA methylation profile of IL-1B and IL-6 5â²-flanking regions in human ovarian epithelial cell lines.We found that ALA induce hypermethylation of IL-1B and IL-6 5â²-flanking regions and is associated to IL-1B and IL-6 mRNA and protein downregulation.These data provide novel insights on the antiinflammatory effects of ALA and support its clinical use in pregnancy complications.
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Journal: PharmaNutrition - Volume 5, Issue 3, September 2017, Pages 77-83