کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5559684 1561692 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The capacity and effectiveness of diosmectite and charcoal in trapping the compounds causing the most frequent intoxications in acute medicine: A comparative study
ترجمه فارسی عنوان
ظرفیت و اثربخشی دوسومکتیت و زغال چوب در دامداری این ترکیبات منجر به مسمومیت بیشتر در پزشکی حاد می شود: یک مطالعه مقایسه ای
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Promethazine and imipramine are the most effectively adsorbed to diosmectite.
- The acidic drugs (acetylsalicylic acid) are poorly adsorbed onto diosmectite.
- Diosmectite and charcoal mostly behave independently or in a bit antagonistic way.

The aim of the study was to compare the adsorption ability of two adsorbent materials, namely diosmectite and activated charcoal towards selected model compounds that are most commonly involved in acute intoxication. Eleven model compounds were selected: acetylsalicylic acid, α-amanitin, amlodipine, digoxin, phenobarbital, ibuprofen, imipramine, carbamazepine, oxazepam, promethazine, and theophylline. Of the tested compounds, promethazine and imipramine were the most effectively adsorbed to diosmectite. Their adsorption to diosmectite (0.356 ± 0.029 mg promethazine/mg diosmectite and 0.354 ± 0.019 mg imipramine/mg diosmectite, respectively) was significantly higher than their adsorption to activated charcoal. The effect of temperature and pH on the adsorption efficiencies was also evaluated. In the case of experiments with mixture of both adsorbents, they mostly behaved in a solution independently or in a slightly antagonistic way. Using various methods such as N2 adsorption and thermogravimetric analysis, the structure and texture of diosmectite and activated charcoal were attained.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 52, June 2017, Pages 214-220
نویسندگان
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