کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5559875 1561695 2017 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E
چکیده انگلیسی
In this study, biochemical changes and histological structure of rat liver after bendiocarb administration and possible preventive effects of vitamins C and E were studied. The animals were given with bendiocarb, vitamin C and vitamin E, daily 0,8 mg/kg of body weight (bw), 100 mg/kg-bw and 100 mg/kg-bw for 28 days, respectively. Lipid peroxidation, antioxidant enzyme activities, histological alterations and antioxidant capacity assays of liver and also liver function tests and lipid profile were measured. Bendiocarb treatment decreased the antioxidant enzyme activities, FRAP and TEAC values and increased malondialdehyde levels compared to control. Also, there were statistically significant alterations in liver function tests, lipid profile parameters and histopathological changes in bendiocarb treated groups. Vitamins C and E showed protective effects against examining parameters. According to results we can say that co-treatment of vitamin C and vitamin E may be more effective than use of them alone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 49, January 2017, Pages 148-155
نویسندگان
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