کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5561019 1562076 2017 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon
ترجمه فارسی عنوان
محافظت از عصب و عصبی در مغز در حال رشد: به روز رسانی در مورد اثرات دگزمودمیدیدین و زنون
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی

Highlight
- Dexmedetomidine (Dex), and xenon (Xe), are effective anesthetic adjuvants and largely devoid of neurotoxicity in the developing brain
- Dex and Xe protect against ongoing neurologic injury, including in the developing brain
- Both Dex and Xe may have potential clinical efficacy in the surgical management of pediatric patients

Growing and consistent preclinical evidence, combined with early clinical epidemiological observations, suggest potentially neurotoxic effects of commonly used anesthetic agents in the developing brain. This has prompted the FDA to issue a safety warning for all sedatives and anesthetics approved for use in children under three years of age. Recent studies have identified dexmedetomidine, the potent α2-adrenoceptor agonist, and xenon, the noble gas, as effective anesthetic adjuvants that are both less neurotoxic to the developing brain, and also possess neuroprotective properties in neonatal and other settings of acute ongoing neurologic injury. Dexmedetomidine and xenon are effective anesthetic adjuvants that appear to be less neurotoxic than other existing agents and have the potential to be neuroprotective in the neonatal and pediatric settings. Although results from recent clinical trials and case reports have indicated the neuroprotective potential of xenon and dexmedetomidine, additional randomized clinical trials corroborating these studies are necessary. By reviewing both the existing preclinical and clinical evidence on the neuroprotective effects of dexmedetomidine and xenon, we hope to provide insight into the potential clinical efficacy of these agents in the management of pediatric surgical patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurotoxicology and Teratology - Volume 60, March–April 2017, Pages 102-116
نویسندگان
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