High serum oxytocin is associated with metabolic syndrome in older men - The MINOS study

- We assessed the association between serum oxytocin (OT) and metabolic syndrome (MetS).
- In older men, higher OT levels were associated with higher odds of MetS.
- High serum OT was associated with MetS regardless of testosterone or vitamin D level.
- The men with high OT and low osteocalcin levels had higher odds of MetS.

AimOxytocin regulates food intake, carbohydrate and lipid metabolism, and urinary sodium excretion. We assessed the association between serum oxytocin levels and presence of metabolic syndrome (MetS) in older men.MethodsCross-sectional study was performed in 540 volunteer men aged 50-85 yrs from the MINOS cohort. Oxytocin was measured in fasting serum by radioimmunoassay (Oxytocin RIA, Phoenix Pharmaceuticals). MetS was diagnosed using the harmonized definition.ResultsSerum oxytocin was higher in 166 men with MetS vs. controls (p < 0.005). After adjustment for confounders including leptin, higher oxytocin was associated with higher odds of MetS (OR = 1.38 per SD, 95%CI: 1.10-1.71, p < 0.005). Men with serum oxytocin >0.74 pg/mL (median) had higher odds of MetS vs. men with oxytocin ⩽0.74 pg/mL (OR = 2.06, 95%CI: 1.33-3.18, p < 0.005). Higher oxytocin levels and low testosterone levels (total or free) were significantly associated with higher odds of MetS jointly and independently of each other. Men having oxytocin >0.74 pg/mL and total testosterone <300 ng/dL (<10.4 nmol/L) had higher odds of MetS vs. men without these characteristics (OR = 3.95, 95%CI: 1.65-9.46, p < 0.005). Men having 25-hydroxycholecalciferol levels <30 ng/mL and oxytocin >0.74 pg/mL had higher odds of MetS vs. men without these characteristics (OR = 2.86, 95%CI: 1.47-5.58, p < 0.01). Men having oxytocin >0.74 pg/mL and osteocalcin levels <14.6 ng/mL (lowest quartile) had higher odds of MetS vs. men without these characteristics (OR = 4.12, 95%CI: 2.07-8.20, p < 0.001).ConclusionIn older men, higher serum oxytocin levels are associated with higher odds of MetS regardless of potential confounders.