|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5590795||1570199||2017||3 صفحه PDF||سفارش دهید||دانلود کنید|
- Unique cortical encephalitis followed by recurrent CNS demyelination was reported.
- The relationship between cortical encephalitis and anti-MOG antibody is unclear.
- NMDAR might be involved during myelin damage induced by anti-MOG antibody.
We report the case of a patient who initially presented with fever, headache and seizure. MRI revealed a fluid attenuation inversion recovery (FLAIR) high-intensity lesion involving the right temporal, parietal and occipital cortex. Afterwards, the patient developed three recurrent episodes, manifested as brainstem encephalitis, optic neuritis and ADEM-like illness successively, indicating demyelination. Both of his serum anti-MOG and CSF anti-NMDAR antibodies were proved positive by transfected cell based assays. We consider our case to have cortical encephalitis due to certain autoimmune mechanism initially, and then developed MOG-antibody mediated recurrent demyelination in the following episodes.
Journal: Multiple Sclerosis and Related Disorders - Volume 18, November 2017, Pages 90-92