کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5621864 | 1579187 | 2017 | 5 صفحه PDF | دانلود رایگان |
- Despite growing evidence on the safety of outpatient treatment many patients with acute PE are still managed as inpatients.
- This study provides further evidence that outpatient treatment is safe in low-risk patients based on their PESI score.
- Our data on patient reported outcome measures support the presumption of a good recovery during outpatient treatment.
BackgroundDespite growing evidence on safe and feasible outpatient treatment for acute pulmonary embolism (PE), the majority of patients is still treated in an inpatient setting. This is probably due to a lack of clear guidelines on this subject.ObjectivesTo evaluate safety and patient reported outcome measures (PROM) on outpatient treatment of acute PE.MethodsWe conducted a prospective cohort study. 250 patients presenting with acute PE and Pulmonary Embolism Severity Index (PESI) class I or II were enrolled. Safety of outpatient treatment was assessed by measuring all-cause mortality, recurrent venous thromboembolism (VTE) and episodes of relevant bleeding, with a follow-up period of four weeks and six months. Additionally, PROM's on outpatient treatment were evaluated by repeatedly measuring VAS-scores for pain and dyspnea during the recovery, and by assessing the improvement in SF-36 scores between admission and after six months.ResultsWe found an all-cause mortality rate of 0.4% (95% CI 0.07-2.23), rate of recurrent VTE of 0% (95% CI 0-1.51) and rate of relevant bleeding episodes of 6.4% (95% CI 3.98-10.14). VAS-scores improved significantly during the first 24-h after admission, and continued to improve significantly after five days of home treatment. SF-36 scores on 6 out of 8 domains improved significantly between admission and after six months.ConclusionsOur study shows that outpatient treatment is safe in selected low-risk patients based on their PESI score. Additionally, our data on patient reported outcome measures support the presumption of a good course of recovery during outpatient treatment.
Journal: Thrombosis Research - Volume 156, August 2017, Pages 172-176