کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5622610 1406182 2016 32 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PerspectivePreclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria
ترجمه فارسی عنوان
بیماری آلزایمر پیشآزمون: تعاریف، تاریخ طبیعی و معیارهای تشخیصی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this “silent” stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 12, Issue 3, March 2016, Pages 292-323
نویسندگان
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