کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5627208 1579668 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum AGR2 as a useful biomarker for pituitary adenomas
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Serum AGR2 as a useful biomarker for pituitary adenomas
چکیده انگلیسی


- The serum AGR2 level was higher in PA patients than that in normal control.
- The serum AGR2 level was higher in PA patients than that with other sellar lesions.
- There is no significant difference of AGR2 level in different PA subtypes.
- The detection of serum AGR2 levels by ELISA has high diagnostic accuracy.
- The larger the tumor size is, the lower the mean serum level of AGR2.

ObjectiveThis study aims to evaluate whether the serum Anterior Gradient-2 (AGR2) can be used as a potential biomarker screening in the diagnosis of Pituitary adenomas(PAs).Patients and methodsThe serum AGR2 protein levels were preoperatively measured in 163 PA patients, 43 patients with other sellar lesions excluding PAs, 7 patients with prostate cancer as a positive control and 20 normal people(10 female and 10 male) using Enzyme-Linked ImmunoSorbent Assay (ELISA). Differences in the serum AGR2 level between different groups were analyzed for statistical significance with a Mann-Whitney U test.ResultsThe data showed that serum AGR2 level was significantly higher in the serum of PA patients (250.10 ± 79.14 ng/ml) than the patients with other sellar lesions (220.84 ± 79.62 ng/ml, P = 0.017) and normal people (163.67 ± 50.38 ng/ml, P < 0.001). Receiver operating characteristic (ROC) curve analysis was used. The detected area under the curve (AUC) was 0.835. The calculated optimal cut-off point for AGR2 level in serum samples was 158.63 ng/ml (Youden index = 0.564). The sensitivity was 91.4% and the specificity was 65.0%. Despite the variety of PA clinical features, the serum level of AGR2 are definite in PAs, although there may be a difference between male or female patients.ConclusionOur data suggests AGR2 as a potential biomarker for the diagnosis of PAs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurology and Neurosurgery - Volume 154, March 2017, Pages 19-22
نویسندگان
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