|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5627971||1579798||2017||3 صفحه PDF||سفارش دهید||دانلود کنید|
- After the inhibition of the primary motor cortex, using repetitive Transcranial Magnetic Stimulation 9 (rTMS), in 7 subjects out of 8, the upgoing thumb sign was observed.
- The upgoing thumb sign is a subtle neurological finding related to the upper motor neuron involvements.
- The upgoing thumb sign may be seen in the primary motor cortex or corticospinal pathways lesions.
BackgroundThe upgoing thumb sign has been frequently observed in patients with minor strokes and transient ischemic attacks as an indicator of brain involvement. We assessed the effect of primary motor cortex (M1) inhibition in the development of the upgoing thumb sign.MethodsUsed repetitive Transcranial Magnetic Stimulation (rTMS, 1Â Hz frequency for 15Â min, 1s ISI, 900 pulses) at 60% of resting motor threshold to inhibit the right or left primary motor cortex of 10 healthy individuals. Participants were examined before and after rTMS by a neurologist who was blind to the site of motor cortex inhibition.Results10 neurological intact participants (5 women/5 men) were recruited for this study. 2 cases were excluded due to pre-existing possible thumb signs. After the inhibition of the primary motor cortex, in 6 subjects out of 8, we observed a thumb sign contralateral to the site of primary motor cortex inhibition. In one subject an ipsilateral thumbs sign was noted. In another case, we did not find an upgoing thumb sign.ConclusionThe upgoing thumb sign is a subtle neurological finding that may be related to the primary motor cortex or corticospinal pathways involvements.
Journal: eNeurologicalSci - Volume 8, September 2017, Pages 31-33