کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5628149 | 1579818 | 2017 | 6 صفحه PDF | دانلود رایگان |
- We compared the rate of IRDA and IRTA events between adult patients with ADHD and healthy controls.
- We detected significantly increased rates of IRDA/IRTA before HV (F = 4.209, p = 0.042) in ADHD patients.
- The increased IRDA/IRTA rates might lead to (para)epileptic short term effects via local area network inhibition.
- The increased IRDA/IRTA rates might lead to long-term effects via connectivistic brain restructuring.
IntroductionAdult attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. In subgroups of patients with a (para)epileptic pathomechanism, this might be due to intermittent rhythmic delta or theta activity (IRDA/IRTA).Participants and methodsUsing a fully data-driven analysis, we compared the IRDA/IRTA rates in the resting electroencephalography (EEG) results of 97 adult patients with ADHD and 30 control subjects. The IRDA/IRTA rates before hyperventilation (HV) and for HV difference (difference between IRDA/IRTA rate after and before HV) were compared between groups using a linear model.ResultsWe detected significantly increased rates of IRDA/IRTA before HV (F = 4.209, p = 0.042) in patients with ADHD but no significant difference between the groups for HV-difference (F = 2.46, p = 0.119).DiscussionThe increased IRDA/IRTA rates before HV in the group with ADHD might lead to (para)epileptic short-term effects (e.g., impulsivity) via local area network inhibition, and to long-term effects (e.g., cognitive deficits) via connectivistic brain restructuring.
Journal: Epilepsy & Behavior - Volume 75, October 2017, Pages 60-65