Surgical outcomes in two different age groups with Focal Cortical Dysplasia type II: Any real difference?

- Children and adults with early epilepsy onset related with FCD type II
- Surgery performed in children or adults with FCD II related epilepsy is analyzed.
- Surgical outcome was favorable in the whole population.
- Disease duration does not influence surgical and cognitive outcome in FCDs II.
- To increase quality of life, surgery should be offered early.

ObjectiveFocal Cortical Dysplasias (FCDs) represent a common architectural cortical disorder underlying drug-resistant focal epilepsy. So far, studies aimed at evaluating whether age at surgery is a factor influencing surgical outcome are lacking, so that data on the comparison between patients harboring Type II FCD operated at younger age and those operated at adult age are still scarce. We compared presurgical clinical features and surgical outcomes of patients with histopathologically diagnosed Type II FCD undergoing surgery at an earlier age with those operated after 20 years of age.MethodsWe retrospectively analyzed 1660 consecutive patients operated at the “Claudio Munari” Epilepsy Surgery Centre. There were 289 patients (17.4%) with a neuropathological diagnosis of Type II FCD. We included two different groups of patients, the first one including patients operated on at less than 6 years, the second sharing the same seizure onset age but with delayed surgery, carried out after the age of 20. Seizure characteristics and, neuropsychological and postoperative seizure outcomes were evaluated by study group.ResultsForty patients underwent surgery before the age of 6 and 66 patients after the age of 20. Surgical outcome was favorable in the whole population (72.6% were classified in Engel's Class Ia + Ic), independently from age at surgery. In the children group, 32 patients were classified in Class I, including 30 (75%) children in classes Ia and Ic. In the adult group, 53 belonged to Class I of whom 47 (71%) were in classes Ia and Ic.The percentage of permanent complications, the surgical outcomes, and AED withdrawal did not significantly differ by study group.ConclusionOur results indicate that there is no difference between the groups, suggesting that outcome depends mainly on the histological findings and not on timing of surgery.