کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5628551 1579885 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sub-cortical brain morphometry and its relationship with cognition in rolandic epilepsy
ترجمه فارسی عنوان
مورفومتری مغز زیر غضروفی و ​​ارتباط آن با شناخت در صرع رواندائی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- We investigated putamen and caudate morphological alterations in children with BECTS, considering the sides of the epilepsy focus.
- Correlations were studied between the sub-cortical morphometry and cognitive indices.
- Putamen and caudate shape alterations exist in BECTS, and sub-cortical morphological changes correlates with cognition.
- Sub-cortical shape alterations and their relation with cognitive functions depend on the epilepsy lateralization.

PurposeRolandic epilepsy (RE), also called benign epilepsy with centrotemporal spikes (BECTS) is the most common childhood epilepsy syndrome. RE is associated with cognitive difficulties, which can affect children's quality of life. The underlying causes of these cognitive impairments are unclear. The objective of this prospective study is to investigate sub-cortical morphological alterations in RE children with left, right, or bilateral hemispheric focus and its association with cognition.MethodsParticipants include 41 children with rolandic epilepsy and 38 healthy controls (age 8-14 years), recruited from CHU Sainte-Justine Montreal Children Hospital (N = 40) and Basel's Children Hospital (N = 39). Quantitative volumetric assessment of putamen and caudate structures was performed on T1-weighted MR scans along with the morphological analysis to test for differences between patients and controls. These analyses were performed considering the side of epilepsy focus in all participants. Correlations were investigated between the sub-cortical morphometry and cognitive indices such as intelligence quotient (IQ), verbal comprehension index (VCI), perceptual reasoning index (PRI), working memory index (WMI), and processing speed index (PSI).ResultsChildren with bilateral BECTS showed statistically significant volume reduction in right caudate (p < .05), while no statistically significant putamen volumetric changes were detected in BECTS participants compared to normal controls. According to a spectral-based groupwise shape analysis, regional alterations were found in both putamen and caudate structures of children with BECTS. In particular, children with left BECTS showed significant outward local deformity in left putamen and individuals with bilateral BECTS showed inward local group differences in both right putamen and right caudate. The correlation assessment showed positive association between the volume of the left caudate and cognitive indices in the group containing all BECTS participants. Negative correlation was found between putamen sub-regional shape alterations and cognition in individuals with right BECTS and in all BECTS participants. Negative associations between caudate sub-regional morphologies and cognitive indices were detected in left cohort.SignificanceWe have confirmed putamen and caudate shape alterations in children with BECTS. However, our results further suggest that variations in sub-cortical shape affect cognitive functions. Importantly, we have demonstrated that shape alterations and their relation with cognition depend on the side of epilepsy focus. Our results point to different syndromic entities in the BECTS population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 138, December 2017, Pages 39-45
نویسندگان
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