کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5628650 1579886 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacoresistance with newer anti-epileptic drugs in mesial temporal lobe epilepsy with hippocampal sclerosis
ترجمه فارسی عنوان
مقاومت دارویی با داروهای ضد صرع جدیدتر در صرع لوب مریالی ملیال با اسکلروز هیپوکامپ
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- The majority (75.3%) of patients with MTLE-HS remain refractory to 2 or more appropriate AED trials.
- Newer AEDs are not more likely to control seizures in MTLE-HS than older AEDs.
- Duration of epilepsy significantly correlates with number of AED trials in seizure free but not pharmacoresistant patients.

This study aims to evaluate the overall prognosis, prognostic factors, and efficacy of treatment in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) who have access to third generation anti-epileptic drugs but not to epilepsy surgery. Eighty-five MTLE-HS patients were retrospectively placed into a seizure-free (seizure-free for >1 year) or drug-resistant group, and the two groups were compared on the basis of age, sex, age at onset of seizures, duration of epilepsy, side of lesion, handedness, EEG findings, history of CNS infection, history of febrile convulsions, history of head trauma, history of cognitive impairment, family history of seizures, number of current anti-epileptic drugs (AEDs), total number of AED trials, and presence of individual AEDs. Only 24.7% of MTLE-HS patients had achieved seizure freedom for >1 year. Poor prognosis and drug-resistance were associated with younger age at onset of seizures (p = 0.002), longer duration of epilepsy (p = 0.018), greater number of current AEDs (p < 0.001), and greater total number of AED trials (p < 0.001). In addition, regimens with newer AEDs had no greater efficacy than regimens with older AEDs. Most medically managed MTLE-HS patients do not achieve seizure freedom despite multiple AED trials, and treatment with third generation AEDs should not preclude evaluation for epilepsy surgery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 137, November 2017, Pages 56-60
نویسندگان
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