Clinical commentaryInfluence of perfluorocarbons on Carbamazepine and Benzodiazepine for a neuro-lung protective strategy

- Oxygen enrichment mechanism leads to neuro-lung protective strategy.
- This is achieved with support of perfluorocarbons along with antiepileptic drugs.
- Co-existence of fluorine and drug ensure oxygen uptake by anatomical system and drug.
- Morphology of TEM, particle diameter and optical images backs up this analysis.

Lennox-Gastaut syndrome (LGS) is commonly characterized by a triad of features including multiple seizure types, intellectual disability or regression. LGS type of seizures is epilepsy which is due to abnormal vibrations occurring in seizures. During the time of such abnormal vibrations, both the seizures and the lungs suffer a lack in oxygen content to a considerable extent. This results in prolonged vibrations and loses of nervous control. As a neuro-lung protective strategy, a novel attempt has been made to enrich both seizures and lungs with oxygen content through the support of Perfluorodecalin (an excellent oxygen carrier) C10F18 (PFD) and Perfluorohexane C6F14 (PFH) along with an enhancement in the antiepileptic activity by the two chosen antiepileptic drugs (AEDs) Carbamazepine (CBZ) and Benzodiazepine (BDZ). Perfluorodecalin C10F18 (PFD) and Perfluorohexane C6F14 (PFH) emulsions were prepared by sonication process with combination of nonionic emulsifier, Lecithin (l-α-phosphatidylcholine) as a surfactant in Aqueous phase medium. These emulsions were mixed with Carbamazepine (CBZ) and Benzodiazepine (BDZ) drugs maintained at a temperature of about −20 °C to 20 °C and were set to slow evaporation process. The products are subjected to Optical microscope, Transmission electron microscopy (TEM) and Scanning Electron Microscope (SEM) - Energy dispersive X-ray Spectroscopy (EDS). Study reveals the co-existence of fluorine and drug ensuring the oxygen uptake by the drug. Morphology of TEM, Optical microscopic images and the particle diameter estimated through Image_J confirms this analysis.

The co-existence of both perfluorocarbons and antiepileptic drugs (AEDs) are well established in SEM, TEM and optical microscopic images. The outer morphology indicates the fluorine content and inner the drug. The adequate fluorine content shown in optical study ensures the oxygen carrying nature of the interfacial system. Further the presence AEDs ensure the antiepileptic activity simultaneously.77