کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5630219 1580371 2017 3 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Contribution of EAE to understanding and treating multiple sclerosis
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موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
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Contribution of EAE to understanding and treating multiple sclerosis
چکیده انگلیسی


- The NIH Neuroimmunology Branch was a major contributor to the development of EAE as a model to study MS.
- EAE has played a major role in understanding the pathology of MS and the development of therapeutics.
- The use of genetically modified mice has identified the role of several molecules in CNS demyelinating disease using EAE.

This article is a summary of a lecture presented at the 40 years of Neuroimmunology meeting held on April 19, 2015, in commemoration of the 40th anniversary of the Neuroimmunology Branch (NIB) at the National Institutes of Health. Experimental autoimmune encephalomyelitis (EAE) has been used as a model for multiple sclerosis (MS) for several decades. There are remarkable similarities between the central nervous system pathology of mice with EAE and MS patients. However, there are distinct differences which limits the contribution of EAE to the understanding of MS. My lecture summarized the role that the NIB played in establishing EAE as a valid model for studying MS, and the role that EAE has played in my own research.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 304, 15 March 2017, Pages 40-42
نویسندگان
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