کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5630324 1580366 2017 3 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Short CommunicationAquaporin-4 antibody positive neuromyelitis optica spectrum disorder associated with esophageal cancer
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موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
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Short CommunicationAquaporin-4 antibody positive neuromyelitis optica spectrum disorder associated with esophageal cancer
چکیده انگلیسی


- Autoimmune diseases may sometimes coexist with neoplasms.
- A 70-year-old woman was diagnosed with AQP4 antibody-positive NMOSD.
- The patient was also diagnosed with an esophageal squamous cell carcinoma.
- Symptoms, imaging findings and AQP4 titer improved with treatment.
- AQP4 antibody-positive NMOSD may be associated with esophageal cancer.

Autoimmune diseases are sometimes associated with neoplasms. A 70-year-old Japanese woman with myelitis, seropositive for aquaporin-4 (AQP4) antibody, was diagnosed with neuromyelitis optica spectrum disorder (NMOSD); thereafter an esophageal squamous cell carcinoma was identified. Immunohistochemically, her cancer was anti-AQP4 antibody negative. Her symptoms, imaging findings and AQP4 titer markedly improved with corticosteroid and anti-cancer therapies. Although AQP4 may be a paraneoplastic antigen, paraneoplastic syndrome could not be definitively diagnosed in this case. Nevertheless, this is the first report of an association between AQP4 antibody-seropositive NMOSD and esophageal cancer. The possibility of underlying malignancy should be considered in patients diagnosed with NMOSD.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 309, 15 August 2017, Pages 38-40
نویسندگان
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