کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5643830 1586479 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes
چکیده انگلیسی


- The ADORA2A gene is related to caffeine consumption and differences in sleep architecture.
- Caffeine consumption may affect sleep in individuals with specific genotypes.
- Genetic variants that influence caffeine response should be further explored.

ObjectiveTo verify the association between c.1083T>C polymorphism in the adenosine receptor A2A gene (ADORA2A) and objective sleep, as well as the correlation between caffeine consumption, sleep parameters, and electroencephalographic spectral power in a large, population-based sample from São Paulo, Brazil.MethodsThis study was conducted in participants of the São Paulo Epidemiologic Sleep Study (EPISONO), a large, population-based survey consisting of a representative sample of the inhabitants of the city from São Paulo, Brazil, according to sex, age (20-80 years), and socioeconomic status in the year 2007. Questionnaires, polysomnography, spectral analysis of sleep electroencephalogram, and c.1083T>C polymorphism genotyping were performed in this study.ResultsWe found that caffeine consumption was positively correlated with sleep latency and α spectral power, as well as negatively correlated with percentage of N3 stage and δ spectral power in this stage. However, this association was identified only in T allele carriers and not in CC genotype.ConclusionOur data support an important aspect of this polymorphism in ADORA2A gene, showing that the variant affects the association between caffeine consumption and objective sleep parameters in a large population-based cohort.Clinical trial informationName: Epidemiology of sleep disturbances among adult population of the Sao Paulo City. URL: http://www.clinicaltrials.gov/ct2/show/NCT00596713?term = NCT00596713&rank = 1. Number: NCT00596713.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Sleep Medicine - Volume 30, February 2017, Pages 210-215
نویسندگان
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