Designing sterile biocompatible moxifloxacin loaded trgacanth-PVA-alginate wound dressing by radiation crosslinking method

- Wound dressings are prepared by gamma-radiation crosslinking.
- Wound dressings are sterile, biocompatible and antioxidant nature.
- Drug moxifloxacin occurred through Fickian diffusion mechanism.
- Drug release profile best fitted in to Kosmeyer Pappas model.
- Drug moxifloxacin is stable after gamma irradiation.

Keeping in view the wound healing potential of tragacanth gum and alginate, in the present work, an attempt has been made to explore the potential of these polysaccharides to prepare the moxifloxacin loaded hydrogel wound dressings for better wound care. These hydrogel dressings have been developed by dual crosslinking method. After forming the super-molecular interactions between tragacanth gum and alginate fiber by calcium ions, further crosslinking has been induced by gamma irradiation in the presence of PVA. Some important biomedical properties of these hydrogel dressings like wound fluid absorption, thrombogenecity, haemolysis, antioxidant activity, mechanical behavior and drug release properties have also been studied. Release of drug moxifloxacin occurred through Fickian diffusion mechanism and release profile was best fitted in to Kosmeyer Pappas model of drug release. Overall, these sterile, biocompatible, antioxidant and mucoadhesive hydrogel wound dressing could be used for the controlled and sustained release of antibiotic drug for better wound healing.

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