|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5653920||1589102||2017||5 صفحه PDF||سفارش دهید||دانلود کنید|
BackgroundColchicine poisoning is an uncommon but serious form of drug intoxication. It may produce life-threatening systemic effects. In toxic doses it produces nausea and vomiting and bone marrow suppression, often leading to sepsis, hypocalcemia, adult respiratory distress syndrome, and direct cardiotoxic effects.ObjectiveThe aim of this study was to describe demographic features and the outcome of patients poisoned with colchicine.MethodsA retrospective study of the pediatric intensive care unit database was performed for patients â¤18Â years of age who had colchicine poisoning between July 2008 and July 2013.ResultsThe total number of patients with drug poisoning in the study period was 144. Nine of 144 were related to colchicine poisoning. The median age was 4Â years (range 20Â months to 16Â years) and the number of females was five. Six of the nine cases presented after ingesting <0.5Â mg/kg, whereas two patients had consumed 0.5 to 0.8Â mg/kg. One patient had received colchicine >0.8Â mg/kg. Three patients died.ConclusionsAmong drug intoxications, colchicines can lead to severe clinical conditions. All patients suspected of having colchicine intoxication should be managed in the pediatric intensive care unit regardless of the actual degree of poisoning.
Journal: The Journal of Emergency Medicine - Volume 52, Issue 4, April 2017, Pages 499-503