کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5655060 | 1407307 | 2017 | 4 صفحه PDF | دانلود رایگان |
AimRelationships between the intestinal microbiota, intestinal permeability and inflammation in the context of risk for obesity-associated disease continue to be of interest. The aim of the study was to examine the associations between intestinal permeability and type 2 diabetes (T2D).MethodsA total of 130 individuals with T2D (age: 57.5 ± 6.2 years (mean ± SD); BMI: 30.4 ± 3.2; 45% female) and 161 individuals without T2D (age: 37.4 ± 12.5 years; BMI: 25.1 ± 3.9; 65% female) were included in the study. Assessment of intestinal permeability included measurement of circulating lipopolysaccharide (LPS), LPS-binding protein (LBP) and intestinal fatty acid binding protein (iFABP) concentrations, which were used for calculation of a derived permeability risk score (PRS). Associations between permeability measures and T2D status were assessed using logistic regression models.ResultsLBP (â¼34%, P < 0.001), iFABP (â¼46%, P < 0.001) and the PRS (â¼24% P < 0.001) were all significantly higher in the T2D affected individuals. Individuals with a PRS in the upper tertile were 5.07 times more likely (CI: 1.72-14.95; P = 0.003) to have T2D when models were adjusted for age, sex and BMI. There was a trend towards improved prediction when including the PRS in models containing age, sex and BMI (AUC: 0.954 versus 0.962; P = 0.06).ConclusionThese data demonstrate differences in measures of intestinal permeability between individuals with and without T2D. The utility of using intestinal permeability measures as a tool for predicting T2D risk in at risk individuals should be further investigated.
Journal: Diabetes & Metabolism - Volume 43, Issue 2, April 2017, Pages 163-166